PT-141
PT-141, also known as Bremelanotide, is a synthetic peptide developed for its potential role in sexual health and libido enhancement. Unlike traditional treatments for sexual dysfunction that act on vascular pathways, PT-141 works directly through the central nervous system by targeting melanocortin receptors, which are involved in sexual arousal and behavior.
Overview
PT-141 is a seven-amino-acid peptide analog of Melanotan II. It primarily interacts with melanocortin receptors (MC1R and MC4R) in the hypothalamus, stimulating pathways associated with sexual arousal. Research indicates that PT-141 may increase sexual desire, improve sexual function, and enhance arousal in both men and women, without directly affecting penile blood flow like PDE5 inhibitors (e.g., Viagra).
- Potential treatment for hypoactive sexual desire disorder (HSDD)
- Acts centrally on melanocortin receptors rather than vascular pathways
- Studied in both male and female sexual dysfunction models
- May influence neurochemical pathways associated with arousal and desire
Specifications
- Peptide Length: 7 amino acids
- Molecular Formula: C50H69N15O9
- Molecular Weight: 1025.21 g/mol
- Other Names: Bremelanotide, PT-141, Melanotan II analog
Research and Clinical Studies
Sexual Arousal and Libido Enhancement
Clinical studies have demonstrated that PT-141 may significantly increase sexual desire and arousal in individuals experiencing hypoactive sexual desire disorder (HSDD). Unlike traditional vasodilatory treatments, PT-141 acts centrally on melanocortin receptors in the hypothalamus, influencing neurochemical pathways involved in sexual behavior.
Mechanism of Action
PT-141 binds to melanocortin receptors (primarily MC4R), which regulate sexual arousal and behavior in the central nervous system. Activation of these receptors triggers neurochemical cascades that increase sexual motivation and responsiveness without directly affecting vascular flow.
Safety and Tolerability
Clinical trials report that PT-141 is generally well-tolerated when administered in controlled settings. Commonly observed side effects include mild nausea, flushing, or headache. The peptide has not been approved for general therapeutic use outside of regulated clinical research.
Usage Considerations
PT-141 is intended strictly for research and laboratory purposes. It is not approved for general therapeutic use or self-administration. Proper laboratory protocols, handling procedures, and safety guidelines must be followed when working with this peptide.
Note: PT-141 (Bremelanotide) peptide is available for research purposes only. Please review and adhere to all applicable Terms and Conditions before ordering.





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