IGF-1 LR3 1MG

IGF-1 LR3

IGF-1 LR3 (Insulin-Like Growth Factor-1 Long Arg³) is a synthetic analog of human insulin-like growth factor-1 engineered for enhanced biological stability and extended half-life. It differs from native IGF-1 by the substitution of arginine at the third amino acid position and the addition of a 13-amino-acid extension at the N-terminus. These structural modifications significantly reduce binding to IGF binding proteins (IGFBPs), allowing for prolonged systemic activity and increased bioavailability in research environments.

Due to its amplified anabolic, mitogenic, and metabolic signaling properties, IGF-1 LR3 is widely investigated in cellular growth, tissue regeneration, muscle hypertrophy, metabolic regulation, and aging research.

Overview

IGF-1 LR3 exerts its biological activity by binding to the IGF-1 receptor (IGF-1R), a transmembrane tyrosine kinase receptor expressed on nearly all cell types. Activation of this receptor triggers multiple intracellular signaling cascades, including the PI3K/Akt and MAPK/ERK pathways, which regulate cellular growth, differentiation, protein synthesis, survival, and glucose metabolism.

Because of its reduced affinity for IGF binding proteins, IGF-1 LR3 remains biologically active for extended durations compared to native IGF-1, producing stronger and more sustained anabolic signaling in experimental models. This property has made IGF-1 LR3 a powerful tool in research focused on hypertrophy, tissue remodeling, metabolic control, and cellular longevity.

• Enhanced anabolic and mitogenic signaling
• Extended biological half-life and increased bioavailability
• Potent stimulator of protein synthesis and cellular growth
• Regulates glucose uptake and metabolic efficiency
• Investigated in muscle, metabolic, regenerative, and aging research

Specifications

• Amino Acid Sequence: Modified IGF-1 with Arg³ substitution and N-terminal extension
• Peptide Length: 83 amino acids
• Molecular Formula: C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₁
• Molecular Weight: ~9111 Da
• Other Names: Long Arg³ IGF-1, IGF-1 LR3

Research and Clinical Insights

Muscle Growth and Protein Synthesis

IGF-1 LR3 plays a central role in stimulating myoblast proliferation, satellite cell activation, and muscle fiber hypertrophy. Through activation of the PI3K/Akt/mTOR pathway, IGF-1 LR3 increases protein synthesis rates while inhibiting proteolytic pathways, resulting in enhanced muscle tissue accretion in experimental models.

Metabolic Regulation and Glucose Utilization

IGF-1 LR3 enhances cellular glucose uptake by increasing GLUT4 translocation to the cell membrane and improving insulin sensitivity. These actions support metabolic efficiency and energy utilization, making IGF-1 LR3 a molecule of interest in metabolic disorder and insulin resistance research.

Tissue Regeneration and Cellular Repair

Research demonstrates that IGF-1 LR3 promotes DNA synthesis, cell cycle progression, and tissue remodeling across multiple organ systems. It accelerates wound healing, enhances connective tissue repair, and supports bone mineralization through osteoblast activation and collagen synthesis.

Neuroprotective and Cognitive Research

IGF-1 signaling has been associated with neurogenesis, synaptic plasticity, and neuronal survival. IGF-1 LR3 is therefore investigated in neurological models examining cognitive performance, neurodegeneration, and central nervous system repair.

Aging and Longevity Studies

Age-related declines in IGF-1 activity correlate with reduced tissue regeneration, metabolic dysfunction, and cellular senescence. IGF-1 LR3 is studied as a potential modulator of age-associated physiological decline by restoring anabolic signaling, mitochondrial efficiency, and cellular resilience.

Usage Considerations

IGF-1 LR3 is supplied strictly for research and laboratory use. It is not approved for human therapeutic application. All handling, storage, and experimental procedures must follow institutional safety guidelines and regulatory standards.

Notice: IGF-1 LR3 is available for research purposes only. Please review and comply with all Terms and Conditions prior to ordering.