CJC-1295

CJC-1295

CJC-1295 is a synthetic peptide analog of growth hormone-releasing hormone (GHRH) that has been engineered for prolonged activity in research applications. By stimulating the pituitary gland to increase growth hormone (GH) secretion, CJC-1295 has become a valuable tool in studies focused on endocrine regulation, muscle growth, metabolic modulation, and age-related hormone research. Its unique design includes modifications that extend half-life, enabling sustained GH release in experimental models.

CJC-1295 is extensively investigated in laboratory research for its potential effects on growth hormone axis modulation, IGF-1 regulation, tissue repair, and metabolic optimization.

Overview

CJC-1295 binds to growth hormone-releasing hormone receptors (GHRH-R) on somatotrophs in the anterior pituitary. Upon receptor activation, adenylate cyclase is stimulated, increasing intracellular cyclic AMP (cAMP) and promoting the synthesis and pulsatile release of growth hormone. The peptide’s extended half-life is due to its ability to bind to circulating albumin, reducing proteolytic degradation and prolonging its biological activity.

Through these mechanisms, CJC-1295 supports increased GH-dependent processes such as protein synthesis, tissue repair, lipolysis, and IGF-1 production. It is widely used in research on endocrine function, regenerative medicine, and metabolic studies.

• Stimulates growth hormone secretion via GHRH receptor activation
• Prolonged biological activity due to albumin binding and reduced degradation
• Supports IGF-1 production, protein synthesis, and tissue repair
• Investigated in endocrine, metabolic, and regenerative research
• Potential applications in muscle growth, anti-aging, and metabolic optimization studies

Specifications

• Peptide Type: Growth hormone-releasing hormone analog
• Amino Acid Length: 30 amino acids (CJC-1295 DAC variant)
• Molecular Formula: C₁₆₅H₂₆₉N₅₁O₄₉S
• Molecular Weight: ~3750 Da
• Other Names: Modified GHRH, CJC-1295 DAC

Research and Clinical Insights

Growth Hormone Axis Modulation

CJC-1295 stimulates the release of endogenous growth hormone from the anterior pituitary, resulting in increased IGF-1 levels in experimental models. This peptide is widely used to study GH-dependent cellular and tissue responses, including protein synthesis, anabolic signaling, and endocrine regulation.

Muscle Growth and Tissue Repair

Research demonstrates that CJC-1295-induced GH elevation can promote muscle cell proliferation, enhance tissue repair, and accelerate recovery processes. These effects are particularly relevant in studies exploring regenerative medicine, skeletal muscle biology, and sarcopenia.

Metabolic Regulation

By increasing GH and IGF-1 levels, CJC-1295 influences lipolysis, energy metabolism, and insulin sensitivity. Experimental models indicate potential benefits for metabolic homeostasis and body composition research.

Anti-Aging and Regenerative Applications

CJC-1295 is investigated in studies of aging due to its ability to stimulate GH/IGF-1 pathways, which may support cellular regeneration, tissue maintenance, and systemic physiological resilience. Research includes exploration of its effects on skin integrity, organ function, and overall longevity markers.

Usage Considerations

CJC-1295 is supplied strictly for research and laboratory use. It is not approved for human therapeutic application. All handling, storage, and experimental use must comply with institutional safety standards and regulatory guidelines.

Notice: CJC-1295 is provided for research purposes only. Please review and adhere to all Terms and Conditions prior to ordering.