Semax
Semax is a synthetic peptide analog of the adrenocorticotropic hormone (ACTH) fragment (4-10) that has been extensively studied for its neuroprotective, nootropic, and cognitive-enhancing properties. It was originally developed in Russia for research on cerebral ischemia and neurological disorders, and has since been investigated for its effects on memory, learning, and brain function.
Overview
Semax is a heptapeptide (seven amino acids) designed to mimic specific sequences of ACTH without exhibiting hormonal activity. Research indicates that Semax may influence brain-derived neurotrophic factor (BDNF) expression, modulate neurotransmitter systems, and support neuroplasticity. It is considered a nootropic peptide due to its potential to enhance cognitive function and improve mental resilience under stress or neurological injury.
- Potential neuroprotective and cognitive-enhancing effects
- May increase BDNF and promote neuronal growth
- Studied for memory improvement, learning enhancement, and attention regulation
- Investigated in cerebral ischemia, stroke recovery, and neurodegenerative models
Specifications
- Peptide Length: 7 amino acids
- Molecular Formula: C38H55N11O9
- Molecular Weight: 841.91 g/mol
- Other Names: N-Acetyl Semax, ACTH(4-10) analog
Research and Clinical Studies
Neuroprotection
Semax has been studied for its neuroprotective effects in models of cerebral ischemia and hypoxia. Research indicates that it may reduce neuronal apoptosis, protect against oxidative stress, and enhance recovery of brain function following ischemic events. By modulating key signaling pathways, Semax is hypothesized to support neuronal survival and brain resilience.
Cognitive Enhancement and Memory
Clinical and preclinical studies suggest that Semax may improve cognitive performance, including learning, memory retention, and attention span. Animal studies indicate upregulation of neurotrophic factors such as BDNF and nerve growth factor (NGF), which are essential for synaptic plasticity and neuronal communication.
Stress and Neurotransmitter Modulation
Semax has been shown to influence neurotransmitter systems, including dopamine, serotonin, and acetylcholine pathways. These effects may contribute to improved mental clarity, focus, and resistance to cognitive decline under stress or fatigue conditions. Some studies suggest a modulatory effect on the hypothalamic-pituitary-adrenal (HPA) axis without inducing hormonal activity.
Usage Considerations
Semax is intended strictly for research and laboratory purposes. It is not approved for human therapeutic use outside of controlled clinical studies. Laboratory handling and storage protocols should be strictly observed, and all safety guidelines adhered to when working with this peptide.
Note: Semax peptide is available for research purposes only. Please review and adhere to all applicable Terms and Conditions before ordering.





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